Rapastinel acetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Rapastinelacetate 是 N-甲基-D-天冬氨酸 (NMDA) 受体的调节剂和甘氨酸位点的部分激动剂，具有持久的抗抑郁作用。

Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects.(In Vivo):Rapastinel acetate (3mg/kg; i.v.) facilitated long-term potentiation (LTP) 1day-2weeks but not 4weeks post-dosing. Biweekly dosing with Rapastinel acetate sustained this effect for at least 8weeks. A single dose of Rapastinel acetate increased the proportion of whole-cell NMDAR current contributed by NR2B-containing NMDARs in the hippocampus 1week post-dosing, which returned to baseline by 4weeks post-dosing.

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Rapastinel acetate (117928-94-6 Free base)

Membrane Transporter/Ion Channel

NMDAR

Lipid|Mitochondria|iron chelator

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491872-39-0

473.52

C20H35N5O8

>98% (HPLC)

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C(C)(O)=O.C(=O)([C@H]1N(C([C@H]([C@@H](C)O)N)=O)CCC1)N2[C@H](C(N[C@@H]([C@@H](C)O)C(N)=O)=O)CCC2

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(-20℃)

With Ice Pack

≥ 2 years